Salary data is based on the Sioux Falls, SD-MN metropolitan area and applied to Sioux Falls using local cost-of-living adjustments.

Microbiologists Salaries in Sioux Falls, SD

Average Base Pay

$71,298/yr

11% below national average

Monthly

$5,942

Hourly

$34

Cost Index

Microbiologists in Sioux Falls, SD earn an average of $71,298 per year, with most salaries falling between $57,038 and $85,558 depending on experience, employer, and specialization. At 11% below the national average, Sioux Falls offers a more modest rate for this role, in part reflecting a local cost of living index of 78. For professionals evaluating a move or negotiating an offer, the headline salary is only part of the picture—what matters most is how far that income actually goes once taxes, rent, and daily expenses are factored in. The sections below break that down in full for Sioux Falls.

Salary Range

The chart below shows the full compensation spectrum for this role, from entry-level to senior positions. The highlighted center bars represent the 25th–75th percentile band where most professionals are paid.

$53K
Low

$71K
Median

$89K
High

25th percentile: $61K75th percentile: $82K

About Microbiologists

Microbiologists study microorganisms—bacteria, viruses, fungi, algae, and protozoa—their biology, ecology, and interactions with hosts and environments. Applied microbiologists work in pharmaceutical manufacturing, food safety, clinical diagnostics, environmental monitoring, and public health. Clinical microbiologists in hospital laboratories identify pathogens from patient specimens—blood cultures, wound swabs, respiratory samples—and perform antimicrobial susceptibility testing to guide treatment. Industrial microbiologists work in pharmaceutical companies to develop and validate manufacturing processes for vaccines, antibiotics, and biologics, ensuring that products are free from microbial contamination. Food microbiologists develop and validate HACCP-based food safety programs, test products for pathogens, and investigate foodborne illness outbreaks. Environmental microbiologists monitor water and soil for microbial contamination and study microbial communities in natural ecosystems. Research microbiologists investigate fundamental questions about microbial physiology, pathogenesis, evolution, and ecology. The application of genomic tools—next-generation sequencing, metagenomics—has transformed microbiology, enabling culture-independent characterization of microbial communities.

What Microbiologists Do

Culture and identify microorganisms from environmental, clinical, or industrial samples
Perform antimicrobial susceptibility testing
Conduct sterility testing and environmental monitoring in controlled manufacturing environments
Validate microbiological test methods and equipment
Investigate microbial contamination events and implement corrective actions
Apply genomic and molecular techniques including PCR, sequencing, and metagenomics
Prepare technical reports and regulatory documentation
Conduct or contribute to microbiology research projects

Key Skills & Qualifications

Aseptic technique and microbial culture methods
Microorganism identification including biochemical and molecular methods
PCR, qPCR, and next-generation sequencing
Good Manufacturing Practice (GMP) microbiology
HACCP and food safety microbiology
Statistical analysis of microbiological data
Technical documentation for regulatory submissions
Biosafety level 2/3 laboratory protocols

Career Path

Microbiology Technician
Microbiologist
Senior Microbiologist
Principal Scientist / Lab Manager
Director of Microbiology / Chief Scientist

Microbiologists Market in Sioux Falls, SD

Salary Competitiveness

Sioux Falls currently pays 11% below the national median for Microbiologists. This gap can reflect a lower regional cost base, thinner employer density, or a surplus of qualified candidates relative to open roles—factors worth factoring into any offer negotiation or relocation calculation.

Cost of Living Impact

Sioux Falls's cost of living runs below the national average, which works in favor of this salary. Essential monthly expenses account for approximately 48% of take-home pay—a ratio that leaves meaningful room for savings, debt reduction, and discretionary spending compared with higher-cost metros.

Effective Purchasing Power

After adjusting for local taxes and cost of living, a Microbiologists earning $71,298 in Sioux Falls reaches a strong purchasing-power position. The effective standard of living this income supports is materially higher than the gross number alone implies—a useful data point for professionals comparing offers across metro areas.

vs. National Avg

-11%

Cost Pressure

48%

Purchasing Power

Strong

Take-Home Pay Calculator

Enter any gross salary to see how federal and state taxes affect your actual take-home pay, broken down by year, month, and week. Results use an estimated effective tax rate of 27% based on this location and income level.

Annual Salary

Take-home (73%)Taxes (27%)

Annual Net

$52,048

Monthly

$4,337

Weekly

$1,001

Eff. Tax Rate

27%

A gross salary of $71,298 for a Microbiologists in Sioux Falls translates to roughly $4,337 in monthly take-home pay after estimated federal and state taxes. Set against monthly living costs of $2,095—covering housing, food, transportation, utilities, and healthcare—that leaves approximately $2,242 per month in disposable income. That margin, not the gross number, is what determines whether you can comfortably cover rent, build savings, and afford discretionary spending in Sioux Falls's current market.

How far does this salary go in Sioux Falls?

Cost of Living in Sioux Falls

Estimated monthly expenses for a single person in Sioux Falls, benchmarked against US regional price indices for housing, food, transportation, utilities, and healthcare.

Cost Index

Below Avg — US average is 100. Based on a single person (1-bed apartment).

🏠Housing / Rent$1,120/mo

🍔Food & Groceries$435/mo

🚗Transportation$115/mo

💡Utilities$150/mo

🏥Healthcare$275/mo

Monthly$2,095

Annual$25,140

Disposable Income$2,242

Financial Reality Check

This section compares estimated monthly take-home pay against typical living costs in Sioux Falls to show your real disposable income—the amount remaining after essential bills are paid each month.

Monthly Take-Home

$4,337

Living Costs

$2,095

Disposable

$2,242

Cost Index

Lifestyle

Comfortable

With a monthly take-home of $4,337, your estimated living costs in Sioux Falls are $2,095 ($25,140/yr). This leaves $2,242 per month in disposable income, indicating a comfortable standard of living. Sioux Falls's cost of living is 22% below the national average.

Overall, a Microbiologists earning $71,298 in Sioux Falls falls into a comfortable lifestyle tier and has meaningful room to save, invest, and absorb unexpected expenses without financial stress. With a cost index of 78, Sioux Falls is 22% more affordable than the national average, which extends your purchasing power. Regardless of tier, prioritizing retirement contributions, an emergency fund of three to six months' expenses, and incremental debt reduction will yield the greatest long-term financial stability—especially as living costs in Sioux Falls continue to evolve.